5′-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1,2-Dicarbonyls
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چکیده
منابع مشابه
Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth.
Nitrogen-containing bisphosphonates, drugs used to treat bone resorption diseases, also have activity against a broad range of protists, including blood-stage Plasmodium spp. Here, we show that new-generation "lipophilic" bisphosphonates designed as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages, with a high (>100) therapeutic index. T...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2015
ISSN: 0893-228X,1520-5010
DOI: 10.1021/acs.chemrestox.5b00148